Pr Jules

A. Hoffmann

Nobel Prize 2011

Pr Jules

A. Hoffmann

Nobel Prize 2011

Pr Jules

A. Hoffmann

Nobel Prize 2011

Activation of Innate Immunity

The Nobel Prize in Physiology or Medicine 2011 was awarded to Bruce A. Beutler and Jules A. Hoffmann “for their discoveries concerning the activation of innate immunity“.

Activation of Innate Immunity

The Nobel Prize in Physiology or Medicine 2011 was awarded to Bruce A. Beutler and Jules A. Hoffmann “for their discoveries concerning the activation of innate immunity“.

Work

When bacteria, viruses and other microorganisms attack our bodies, our immune system goes to work. It has two lines of defense, the innate immunity and the adaptive immunity. Bruce Beutler and Jules Hoffman have contributed to our understanding of how so-called receptors detect microorganisms and activate our innate immunity. In 1996, by studying fruit flies with mutations, Jules Hoffmann showed that the so-called Toll-gene is active in the development of receptors which are crucial for the immune system of the fly.

Life

Jules Hoffmann was born in Echternach, Luxembourg, and later studied biology at the university in Strasbourg, France, where he earned his doctoral degree in 1969. After a period of residence in Marburg, Germany, Hoffman returned till Strasbourg, where he has served as a director of research laboratories under the French national research institute Centre National de la Recherche Scientifique (CNRS). He has also served as a professor at the university in Strasbourg.

Link with Vilber

Professor Jules Hoffmann’s laboratory is equipped with two Fusion FX7 at the C.N.R.S., Starsbourg, France.

Key publications

Liu X, Sano T, Guan Y, Nagata S, Hoffmann JA, et al. (2012)
Drosophila EYA Regulates the Immune Response against DNA through an Evolutionarily
Conserved Threonine Phosphatase Motif. PLoS ONE 7(8): e42725. doi:10.1371/journal.pone.0042725